1 2 3 4 5 6 7 8 9 10 Changes in reward contingency modulate the trial to trial variability of 11 hippocampal place cells 12 Andrew
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چکیده
44 Pyramidal cells in the rodent hippocampus often exhibit clear spatial tuning. Theories of 45 hippocampal function suggest these ‘place’ cells implement multiple, independent neural 46 representations of position (maps), based on different reference frames or environmental 47 features. Consistent with the ‘multiple maps’ theory, previous studies have shown that 48 manipulating spatial factors related to task performance modulates the within-session 49 variability (overdispersion) of cells in the hippocampus. However, the influence of 50 changes in reward contingency on overdispersion has not been examined. To test this, 51 we first trained rats to collect food from three feeders positioned around a circular track 52 (task1). When subjects were proficient, the reward contingency was altered such that 53 every other feeder delivered food (task2). We recorded ensembles of hippocampal 54 neurons as rats performed both tasks. Place cell overdispersion was high during task1, 55 but decreased significantly during task2, and this increased reliability could not be 56 accounted for by changes in running speed or familiarity with the task. Intuitively, 57 decreased variability might be expected to improve neural representations of position. To 58 test this, we used Bayesian decoding of hippocampal spike trains to estimate subjects’ 59 location. Neither the amount of probability decoded to subjects’ position (local 60 probability) nor the difference between estimated position and true location (decoding 61 accuracy) differed between tasks. However, we found that hippocampal ensembles were 62 significantly more self-consistent during task2 performance. These results suggest that 63 changes in task demands can affect the firing statistics of hippocampal neurons, leading 64 to changes in the properties of decoded neural representations. 65
منابع مشابه
Andrew M . Wikenheiser and A . David Redish trial - to - trial variability of hippocampal place cells Changes in reward contingency modulate the
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Changes in reward contingency modulate the trial-to-trial variability of hippocampal place cells.
Pyramidal cells in the rodent hippocampus often exhibit clear spatial tuning. Theories of hippocampal function suggest that these "place cells" implement multiple, independent neural representations of position (maps), based on different reference frames or environmental features. Consistent with the "multiple maps" theory, previous studies have shown that manipulating spatial factors related t...
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position -4 C50 C49 C48 C47 C46 C45 C44 C43 C42 C41 C40 C39 C38 C37 C36 C35 C34 C33 C32 C31 C30 C29 C28 C27 C26 C25 C24 C23 C22 C21 C20 C19 C18 C17 C16 C15 C14 C13 C12 C11 C10 C9 C8 C7 C6 C5 C4 C3 C2 C1 C0 C-index SD P-value mark A 5 7 9 1 8 4 6 2 1 4 8 7 6 9 3 4 3 7 15 10 6 6 9 3 2 5 3 6 8 9 6 3 5 7 7 10 4 7 7 8 5 5 8 2 2 3 1 2 5 5 9 0.618 0.317 8.27E-03 n.s. A C 3 1 2 0 2 3 3 1 1 2 1 7 4 9 1 ...
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تاریخ انتشار 2011